“Certified & FDA”
Evidence →“GMP-certified” describes factory processes, not what is in the bottle. The claim does not name a certifier or public register that a shopper can check.
Exact product checked · GTIN 0074098522550921st Century · checked Sep 2, 2026USPTO returned 3 exact supplement-class owner records · inspect the identity trail
Quick read · 21st Century
21st Century Niacinamide 500 mg Prolonged Release…
Checked against public sources between July 25 and September 2, 2026 · LookCloser does not sell or recommend supplements.
110tablets
Does the marketing hold up?
FDA recall appears in this brand's history. An exact-product recall is a direct signal. A different product from the same firm is company context, not a strike against this item.
Is the dose real?Panel read — dose not verified2 ingredients listed; no advertised amount we could confirm against them
What a serving costsNo price found for this exact barcode
Is it tested?Claimed — no lab or certificate found
Who’s behind it?USPTO lists 3 owner recordssame brand name, more than one registrant — we don’t choose between them
Is it the real thing?✓Barcode matches outside records
Trouble on record?Brand history — not this product
“Couldn’t verify” means we looked and found no public proof — not a mark against the product. Most supplement claims cannot be independently verified by anyone, so grey is the normal state of this industry.
1◖ partly confirmed1? couldn’t verifyno contradictions · brand-level recall on file
The label itself
What the Supplement Facts panel says
| Niacinamide | 500 mg |
|---|---|
| Calcium (as Calcium Carbonate) | 160 mg |
Printed on the package: GLUTEN FREE · NON-GMO · Vegan Friendly · Third-Party Lab Tested · Packaged in the U.S.A.
We read 2 lines from the package photograph. It is our transcript of the label, not the manufacturer’s panel, and it may be incomplete.
Marketing claims, checked
The checks, one by one
The public sources did not settle the marketing promises on this label.
◐Partly confirmed1
Ingredient research can support context, but it is not a trial of this exact product.
?Couldn’t verify independently1
“Lab”
Evidence →No named laboratory or lot-specific certificate was found for this exact product. No exact brand product page was available for a document check. IFOS, USP, and Informed-Sport were not checked in this record. This is a public-evidence limit, not a finding that testing did not occur.
We looked and found no public proof. That does not count against the product.
Quick read · 4 useful findings
What is worth knowing.
Headlines first. Open evidence only when you want the source trail.
Needs explanationAny trouble in public records?
FDA recall appears in this brand's history
An exact-product recall is a direct signal. A different product from the same firm is company context, not a strike against this item.
Evidence and sources
This recall is not about the product on this page. Twenty-First Century Healthcare, Inc recalled a different product on May 7, 2021. FDA has since closed that case. The recalled item was “21st Century Vitamin D3 125 mcg (5000 IU) tablet, 100 count, UPC 7-40985-27431-6, 21st…”
Locked evidence record →Open the full source-linked findingPublic contextWho is behind it?
Registered owner records: Twenty-First Century Laboratories, Inc. · Twenty-First Century HealthCare, Inc. · Twenty First Century Nutritional Products, Inc.
The public ownership record is ambiguous. We show the exact candidates instead of choosing one by name similarity.
Evidence and sources
USPTO returned multiple live supplement-class records for the exact brand wordmark: Twenty-First Century Laboratories, Inc., Twenty-First Century HealthCare, Inc., Twenty First Century Nutritional Products, Inc.. …
Locked evidence record →Open the full source-linked findingCheckedIs the label honest?
Every ingredient shows its amount · 2 ingredients listed.
Every ingredient shows its real amount — nothing is hidden in a proprietary blend.
Evidence and sources
The panel gives a per-ingredient amount rather than hiding quantities inside a proprietary blend, so each one can be compared to published research.
Locked evidence record →Open the full source-linked findingCheckedCan you trust the review pattern?
We can see 33 of this product’s 420 reviews — the count rose between October 30, 2025 and August 17, 2026. That is too small a slice to say anything about the wider pattern.
A count that moves steadily is ordinary. A sudden burst is what deserves a closer look.
Evidence and sources
Written reviews rose from 387 to 420 between October 30, 2025 and August 17, 2026. The largest rise inside any single 30-day window was about 7, so the count moved in steps rather than in one burst.
Locked evidence record →Open the full source-linked findingWhat remains open 2
- We have not found a public label filing for this exact product.
- Barcode checksum is valid; no independent product record was found.
These are evidence gaps, not strikes against the product.
Who owns the brand wordmark?
The brand has 3 exact supplement-class records
These are the USPTO records behind the brand name. We show them all rather than choosing one by similarity.
🇺🇸Twenty-First Century Laboratories, Inc.
ARIZONA, USA · Registration 3645342
2119 South Wilson Street, Tempe, ARIZONA 85282, UNITED STATES
Goods covered by this record
IC 005: vitamins, mineral supplements, dietary supplements, nutritional supplements, weight loss supplements, herbal supplements, herbal teas for weight loss, vitamins for pets, nutritional supplements for pets, dietary supplements for pets, and herbal supplements for pets.
🇺🇸Twenty-First Century HealthCare, Inc.
ARIZONA, USA · Registration 4085491
443 West Alameda Drive, Tempe, ARIZONA 85282, UNITED STATES
Goods covered by this record
IC 005: Vitamins; mineral supplements; dietary supplements; nutritional supplements; herbal supplements [ ; weight loss supplements; vitamins for pets; nutritional supplements for pets; dietary supplements for pets; herbal supplements for pets; food supplements for pets; ear drops for pets; ear cleaning pads for pets impregnated with medicated skin care cleaners; ear preparations in the nature of medicated powders for pets to eliminate odor and to relieve itching and irritation; first aid kits for pets; self-adhering flexible bandages for pets; pain relief medication for pets; medicated pet shampoo; anti-itch preparations for pets, namely, medicated sprays, powders, lotions and shampoo; medicated lotions and pads to remove tear and saliva stains from the coats of pets; styptic preparations, namely, powders, for pets; and hydrocortisone preparations, namely, anti-itch lotions, sprays and shampoo, for pets ].
🇺🇸Twenty First Century Nutritional Products, Inc.
ARIZONA, USA · Registration 1790110
2445 West 12th Street, Tempe, ARIZONA 85281, UNITED STATES
Goods covered by this record
IC 005: vitamins, herbal remedies and nutritional supplements.
This answers who owns registrations for the brand wordmark. It does not by itself prove which entity made, imported, or sold this specific product. Open USPTO source ↗
Where it sells
Price check for this exact product
Amazon
Exact UPC/GTIN match$5.49
matching UPC/GTIN · checked Sep 2, 2026
View on Amazon ↗iHerb
Exact UPC/GTIN match$5.49
matching UPC/GTIN · checked Jul 25, 2026
View on iHerb ↗Target
Exact UPC/GTIN match$9.01
matching UPC/GTIN · checked Jul 25, 2026
View on Target ↗Walmart
Not confirmedNo exact listing saved
We only show a price when the seller publishes the same barcode as the bottle. We haven’t found that match here.
Search Walmart ↗Same UPC/GTIN observed across 3 sellers. Amazon was lowest at $5.49; Target was highest at $9.01 — a $3.52 range at check time.
No official brand storefront is confirmed in this record. That is neutral, but it prevents a direct brand-price, label, review, and document check.
Reference prices only · no affiliate links · every compared seller must publish the matching UPC/GTIN.
Want to inspect the evidence?
The full report shows every source, the exact unresolved question, and the documentation that would settle it.
Record built September 03, 2026. Sources: source listing observed at check time · USPTO Trademark Search · Keepa exact-listing history · NIH / published research · certification and regulator records where available. LookCloser publishes evidence and gaps; it does not advise for or against any supplement. Evidence-based corrections welcome.