“GMP-certified” describes factory processes, not what is in the bottle. The claim does not name a certifier or public register that a shopper can check.

21st Century Niacinamide 500 mg Prolonged Release…
Checked against public sources on July 25, 2026 · LookCloser does not sell or recommend supplements.
Does the marketing hold up?
FDA recall appears in this brand's history An exact-product recall is a direct signal. A different product from the same firm is company context, not a strike against this item.
“Couldn’t verify” means we looked and found no public proof — not a mark against the product. Most supplement claims cannot be independently verified by anyone, so grey is the normal state of this industry.
The checks, one by one
The public sources did not settle the marketing promises on this label.
◐Partly confirmed1
Ingredient research can support context, but it is not a trial of this exact product.
What is worth knowing.
Headlines first. Open evidence only when you want the source trail.
FDA recall appears in this brand's history
An exact-product recall is a direct signal. A different product from the same firm is company context, not a strike against this item.
Evidence and sources
Brand-level context only, not a finding about this product. Twenty-First Century Healthcare, Inc recalled a different or not-exactly-bound product on 2021-05-07: “A small quantity of bottles of Vitamin D3 125 mcg ((5000 IU) 100 ct. were mislabeled as Vitamin D3 25 mcg (1000 IU). …
Locked evidence record →Open the full source-linked findingRegistered owner records: Twenty-First Century Laboratories, Inc. · Twenty-First Century HealthCare, Inc. · Twenty First Century Nutritional Products, Inc.
The public ownership record is ambiguous. We show the exact candidates instead of choosing one by name similarity.
Evidence and sources
USPTO returned multiple live supplement-class records for the exact brand wordmark: Twenty-First Century Laboratories, Inc., Twenty-First Century HealthCare, Inc., Twenty First Century Nutritional Products, Inc.. These records answer who owns registrations for the brand; the sepa…
Locked evidence record →Open the full source-linked findingEvery ingredient shows its amount · 2 ingredients listed.
Every ingredient shows its real amount — nothing is hidden in a proprietary blend.
Evidence and sources
The panel gives a per-ingredient amount rather than hiding quantities inside a proprietary blend, so each one can be compared to published research.
Locked evidence record →Open the full source-linked findingReviews grew steadily — about 19 between February 27, 2026 to July 20, 2026, with no sudden spike.
Gradual growth is more ordinary. A sudden burst deserves a closer look.
Evidence and sources
Written reviews grew from 398 to 415 across 2026-03-27 – 2026-07-20 with no single manufactured spike (largest 30-day gain ~7).
Locked evidence record →Open the full source-linked findingWhat remains open 2
- No matched to this exact product public label filing is saved in this record.
- Barcode checksum is valid; no independent product record was found.
These are evidence gaps, not strikes against the product.
The brand has 3 exact supplement-class records
These are the USPTO records behind the brand name. We show them all rather than choosing one by similarity.
ARIZONA, USA · Registration 3645342
2119 South Wilson Street, Tempe, ARIZONA 85282, UNITED STATES
Goods covered by this record
IC 005: vitamins, mineral supplements, dietary supplements, nutritional supplements, weight loss supplements, herbal supplements, herbal teas for weight loss, vitamins for pets, nutritional supplements for pets, dietary supplements for pets, and herbal supplements for pets.
ARIZONA, USA · Registration 4085491
443 West Alameda Drive, Tempe, ARIZONA 85282, UNITED STATES
Goods covered by this record
IC 005: Vitamins; mineral supplements; dietary supplements; nutritional supplements; herbal supplements [ ; weight loss supplements; vitamins for pets; nutritional supplements for pets; dietary supplements for pets; herbal supplements for pets; food supplements for pets; ear drops for pets; ear cleaning pads for pets impregnated with medicated skin care cleaners; ear preparations in the nature of medicated powders for pets to eliminate odor and to relieve itching and irritation; first aid kits for pets; self-adhering flexible bandages for pets; pain relief medication for pets; medicated pet shampoo; anti-itch preparations for pets, namely, medicated sprays, powders, lotions and shampoo; medicated lotions and pads to remove tear and saliva stains from the coats of pets; styptic preparations, namely, powders, for pets; and hydrocortisone preparations, namely, anti-itch lotions, sprays and shampoo, for pets ].
ARIZONA, USA · Registration 1790110
2445 West 12th Street, Tempe, ARIZONA 85281, UNITED STATES
Goods covered by this record
IC 005: vitamins, herbal remedies and nutritional supplements.
This answers who owns registrations for the brand wordmark. It does not by itself prove which entity made, imported, or sold this specific product. Open USPTO source ↗
Price check for this exact product
Amazon
Exact UPC/GTIN matchmatching UPC/GTIN · checked Jul 26, 2026
View on Amazon ↗iHerb
Exact UPC/GTIN matchmatching UPC/GTIN · checked Jul 25, 2026
View on iHerb ↗Target
Exact UPC/GTIN matchmatching UPC/GTIN · checked Jul 25, 2026
View on Target ↗Walmart
Not confirmedSearch results remain not linked to this exact product until this retailer publishes the matching UPC/GTIN.
Search Walmart ↗Same UPC/GTIN observed across 3 sellers. Amazon was lowest at $5.49; Target was highest at $9.01 — a $3.52 range at check time.
No official brand storefront is confirmed in this record. That is neutral, but it prevents a direct brand-price, label, review, and document check.
Reference prices only · no affiliate links · every compared seller must publish the matching UPC/GTIN.
Want to inspect the evidence?
The full report shows every source, the exact unresolved question, and the documentation that would settle it.
Record built July 25, 2026. Sources: source listing observed at check time · USPTO Trademark Search · Keepa exact-listing history · NIH / published research · certification and regulator records where available. LookCloser publishes evidence and gaps; it does not advise for or against any supplement. Evidence-based corrections welcome.