Every ingredient amount is disclosed
The panel gives a per-ingredient amount rather than hiding quantities inside a proprietary blend, so each one can be compared to published research.
Full record · lc-821a751e · back to the summary
Designs for Health Homocysteine Supreme - Methylated B Vitamins with Riboflavin
Exact product checkedGTIN not published · checked 2026-08-17
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How to read this report
What this is. We compare what a listing claims against what public records show — label arithmetic, barcode registries, NIH’s label catalog, FDA enforcement data, certification registries, and published research. Every statement below traces to one of those.
What the states mean. Confirmed = an outside source agrees. Contradicted = an outside source disagrees. Caution = something needs explaining. No data = we looked and found nothing — a gap, not a strike.
What it is not. A clean record is not an endorsement and never proof a product works. A thin record is not an accusation. We publish evidence and gaps; the conclusion is yours. Nothing here is medical advice.
Something wrong? Every figure is meant to be checkable — sources are named and linked. Send a correction and we’ll fix the record.
Panel, decoded
What the label discloses
6listed rows
6separately quantified
0combined blend totals
The listing-image panel publishes an amount for each of its 6 listed rows. That supports ingredient-by-ingredient review; it does not verify the contents.
| Panel row | Amount | %DV | What to notice |
|---|---|---|---|
| Riboflavin (as Riboflavin-5-Phosphate) | 30 mg | — | |
| Vitamin B-6 (as Pyridoxal-5-Phosphate) | 10 mg | — | |
| Folate (as Quatrefolic® [6S]-5-methyltetrahydrofolate, glucosamine salt) | 3400 mcg DFE | — | |
| Vitamin B-12 (as Methylcobalamin) | 1000 mcg | — | |
| Trimethylglycine (TMG) | 900 mg | — | |
| L-serine | 100 mg | — |
FDA rules (21 CFR 101.36) require the amount of each dietary ingredient per serving unless hidden in a listed “proprietary blend” (legal, but a transparency yellow flag). A label stating no amount at all is non-compliant — a checkable red flag. This panel states amounts; the open question is whether those listed amounts are independently verified and how they compare with relevant research.
vision:claude-cli:subscription Amounts are shown as listed panel data, not independently lab-tested contents.
Every check we ran
Confirmed evidence
What checked out2
These checks found support in the public record. They confirm specific facts, not the product as a whole.
Confirmed
Exact trademark owner identified
USPTO lists Designs for Health, Inc. (CORPORATION) in CONNECTICUT, USA; DELAWARE, USA for the exact brand wordmark. This identifies the USPTO mark owner or applicant; it does not by itself prove who manufactures or sells this product.
Documented concerns
What needs caution0
These are documented contradictions or claims that need more evidence. They are separate from missing data.
No contradictions or product-specific cautions were found at this check depth.
Unresolved public record
What is still missing5
We looked for these signals but could not settle them from public sources. A gap is not a strike.
Multi-ingredient formula — panel read, serving weight unknown
We read the full Supplement Facts panel from the listing-image panel (below), but the label doesn’t state a serving weight, so the arithmetic can’t run. A gap in the label’s information, not evidence of a problem.
Certified by NSF — contents and contaminants checked
Designs for Health appears in NSF’s certified-products registry with 10 certified product(s), but we couldn’t confirm this exact listing is among them. Certification covers contents and contaminants — not effectiveness.
No recall found — which is not the same as being tested
This means only that no enforcement record matched the brand name — it does not mean the product was tested, reviewed, or cleared by FDA. New and untested products also have no recall records.
This item belongs to a catalog variation family
The paid catalog links this exact item to a parent listing. Review counts on public product pages may be shared across sizes, flavors, or other variants, so the count history is listing context — not evidence that reviewers received or tested this exact variant.
180-day review-count history is on file
Exact-listing history records written-review counts from 25 on 2025-07-18 to 40 on 2026-08-10 (net +15). Count movements can reflect sales, listing variants, collection resets, or moderation; this history does not establish whether reviews are authentic.
What to ask and check
What would settle the open questions
Why is this shown?
Everything we couldn’t verify is something a person can still ask about. Rather than leave gaps sitting as dead ends, we turn each one into a specific question — the exact document, citation, or number that would settle it — plus the things you can confirm yourself with the bottle in your hand.
Ask the brand or seller
1
What is the product’s UPC or GTIN?
The barcode is how a product gets matched to outside records — certification registries, label databases, recall data. Without it, almost nothing can be cross-checked.
2
Is this label filed with NIH’s Dietary Supplement Label Database (DSLD)?
Filing is voluntary, so absence proves nothing — but a filed label puts the full ingredient table on public record where anyone can read it.
Most brands and sellers publish a contact route. A clear answer adds evidence to the record; no answer leaves the question open.
Check for yourself — no one’s permission needed
1
Compare the panel on the bottle in your hand to the one shown in this record.
Ours was read from listing photos and can contain reading errors. The physical label is the source of truth — if they disagree, tell us and we’ll correct the record.
2
Look the product up yourself in NSF’s certified-products registry.
Search “Designs for Health” at info.nsf.org — certification covers contents and contaminants, not effectiveness.
3
Check the lot number and expiry on the bottle against any COA you’re given.
A certificate that doesn’t name your lot doesn’t describe what you’re holding.
These are the open questions on this specific record — not a warning about the product, and not a suggestion to buy or avoid it. Getting them answered is how you decide for yourself.
What the listing promises — claim by claim
Why is this shown?
A listing’s promises are the reason people buy. Each one gets its own row: what was promised, what evidence would settle it, and what we could actually find. We never call a claim false — only whether proof proportionate to it exists on the public record.
| Claim | Status | What we found |
|---|---|---|
| Manufacturing claim “…GMP…” | Partly supported We looked for: the facility registration or certificate behind the claim | “GMP-certified” describes factory processes, not what is in the bottle. The claim does not name a certifier or public register that a shopper can check. |
| Benefit claim “Designs for Health Homocysteine Supreme - Methylated B Vitamins with Riboflavin, B6, B12, Folate, L-Serine & TMG for Brain Support & Heart Health - Methylated Multivitami” | Not checked yet We looked for: whether the ingredient doses on the label match the doses used in published research | Ingredient-level evidence for this formula isn’t in our knowledge base yet. Recorded as not checked yet — not as a negative. |
“No evidence located” does not mean a claim is false — it means the seller has not put evidence proportionate to the claim on the public record, and we could not find any. Absence of proof is not proof of absence.
Verifiability profile — 2 of 6 public signals
✓ Supplement Facts visible in photos✓ Brand's own store found· Per-serving dose established — not published· UPC / GTIN published — not published· Found in NIH's label catalog (DSLD) — not published· Third-party lab named or registry-certified — not published
What this listing gives the public to check. Publishing these signals doesn't prove quality — but withholding them means claims can only be taken on faith.
Identity
| LookCloser record ID | lc-821a751e (internal — no barcode published, which limits cross-checking) |
| Brand | Designs for Health |
| Source listing identifier | B00DJE2WP0 |
| Retailer listing title | Designs for Health Homocysteine Supreme - Methylated B Vitamins with R… show full titleDesigns for Health Homocysteine Supreme - Methylated B Vitamins with Riboflavin, B6, B12, Folate, L-Serine & TMG for Brain Support & Heart Health - Methylated Multivitamin (60 Capsules) |
| USPTO brand owner | Designs for Health, Inc. · CORPORATION · CONNECTICUT, USA; DELAWARE, USA |
| Owner filed address | 2 North Road, East Windsor, CONNECTICUT 06088, UNITED STATES |
From the label (photo-read)
| Serving size | Serving Size 2 capsules |
| Servings per container | 30 |
| Pack statement | 60 Vegetarian Capsules |
| Badges printed on pack | GOOD MANUFACTURING CERTIFIED, GMP, NSF |
Supplement Facts panel (photo-read):
| Ingredient | Amount per serving | Reading confidence |
|---|---|---|
| Riboflavin (as Riboflavin-5-Phosphate) | 30 mg | High clearly legible in the photo |
| Vitamin B-6 (as Pyridoxal-5-Phosphate) | 10 mg | High clearly legible in the photo |
| Folate (as Quatrefolic® [6S]-5-methyltetrahydrofolate, gluco | 3400 mcg DFE | High clearly legible in the photo |
| Vitamin B-12 (as Methylcobalamin) | 1000 mcg | High clearly legible in the photo |
| Trimethylglycine (TMG) | 900 mg | High clearly legible in the photo |
| L-serine | 100 mg | High clearly legible in the photo |
Claims printed on the packaging:
“Methylation support” · “Dietary Supplement” · “CARDIOVASCULAR HEALTH” · “Professional Use Only” · “#1 PRACTITIONER SUPPLEMENT BRAND RECOMMENDED BY FUNCTIONAL MEDICINE PROFESSIONALS WHO KNOW OF DFH” · “Methylfolate | B12 | Trimethylglycine (TMG)” · “Homocysteine Metabolism Support*” · “Promote cardiovascular health, detox, and healthy aging*”
Read by a vision model from 8 listing photos — verbatim extraction; OCR errors possible. Spot a mistake? It will be corrected on review.
Where it sells
We found a brand storefront, but we could not match any price on it to this exact product when we checked.
Official brand domain: www.designsforhealth.com. This storefront does not expose a complete public catalog count.
Reference links for identification only — LookCloser has no affiliate relationships and earns nothing from any link on this page.
Ingredient science
No knowledge-base entry yet for this formula's active ingredients — entries are added as the KB grows. Absence of a science card is a coverage gap, not a judgment.
Ingredient science — NIH references
Riboflavin — NIH ODS · MedlinePlus · PubMed (3,172) · no UL established
Folate — NIH ODS · MedlinePlus · PubMed (10,628) · UL 1000 mcg (synthetic folic acid from supplements/fortified food)
Reference data from the NIH Office of Dietary Supplements, IOM Dietary Reference Intakes, and PubMed. A Tolerable Upper Intake Level is a documented reference figure, not a safety verdict — both the listed amount and the reference are shown for your own judgment. LookCloser gives no medical advice.
Record lc-821a751e · built August 17, 2026 · lookcloser.ai · corrections@lookcloser.ai